Leonard Colebrook (1883?1967)

Leonard Colebrook, 1883-1967.

Leonard Colebrook?s Use of Sulfonamides as a Treatment for Puerperal Fever (1935?1937)

Between 1935 and 1937, Leonard Colebrook showed that sulfonamides, a class of antibacterial drugs, worked as an effective treatment for puerperal fever. Puerperal fever is a bacterial infection that can occur in the uterus [2] of women after giving birth. At the time of Colebrook?s study, puerperal fever remained a common disease due to both the lack of hygienic practices in hospitals and a tre...

Dora Colebrook and the evaluation of light therapy.

At the end of the 19th century, Niels Finsen – a Dane – had shown convincing evidence that tuber-culous infection of the skin (lupus vulgaris) could be treated successfully with intensive light therapy, 1 and he received the Nobel Prize for this work in 1903. 2 Experiments using artificially-produced ultraviolet or visible light for treatment continued in the early 20th century, and they led to...

Marcus Gunn phenomenon with paradoxical oculo-palpebral movements.

THE following case of congenital ptosis with Marcus Gunn phenomenon (Gunn, 1883) is interesting because of its unusual association with multiple paradoxical oculo-palpebral movements (Duke-Elder, 1952). Case Report An 18-year-old girl came for cosmetic correction of a congenital ptosis of the right upper lid with alternate divergent strabismus of about 150. The Marcus Gunn phenomenon was also p...

Efficient resolution of the Colebrook equation

A robust, fast and accurate method for solving the Colebrook-like equations is presented. The algorithm is efficient for the whole range of parameters involved in the Colebrook equation. The computations are not more demanding than simplified approximations, but they are much more accurate. The algorithm is also faster and more robust than the Colebrook solution expressed in term of the Lambert...